Description

(E)-Methyl-2-(2-Bromomethylphenyl)-2-Methoxyiminoacetate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the cephalosporin class of antibiotics, where it serves as a key building block. It is essential for manufacturers in the pharmaceutical and fine chemical industries requiring precise molecular architecture for developing next-generation antimicrobial agents.

Application

• Key Intermediate for Cephalosporin Antibiotics: Primarily used in the synthesis of advanced 3rd and 4th generation cephalosporin drugs, such as cefdinir and cefixime.
• Pharmaceutical Research & Development: Serves as a crucial building block in medicinal chemistry for creating novel β-lactam structures with enhanced efficacy.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce the methoxyiminoacetate moiety, a common pharmacophore in antibiotics.
• API Manufacturing: An essential raw material for contract manufacturing organizations (CMOs) and large-scale API producers ensuring robust supply chains for critical medicines.

Basic Information

Product Name	(E)-Methyl-2-(2-Bromomethylphenyl)-2-Methoxyiminoacetate
CAS No.	133409-72-0
Molecular Formula	C12H14BrNO3
Molecular Weight	300.15 g/mol
Synonyms	Methyl (E)-2-(2-(bromomethyl)phenyl)-2-(methoxyimino)acetate; (E)-Methyl O-Methyl-2-(2-bromomethylphenyl)-2-oximoacetate; 2-(2-Bromomethylphenyl)-2-methoxyiminoacetic Acid Methyl Ester; (E)-2-(2-Bromomethylphenyl)-2-methoxyiminoacetic Acid Methyl Ester; Cefdinir Intermediate; Cefixime Intermediate; ATMO Ester; Z-2-(2-Bromomethylphenyl)-2-methoxyiminoacetic Acid Methyl Ester (common isomer designation)
EINECS	Contact for details

Quality Control

Our (E)-Methyl-2-(2-Bromomethylphenyl)-2-Methoxyiminoacetate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing including HPLC, NMR, and IR spectroscopy to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Isomeric Purity (E-Isomer)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.