Description

4(3H)-Quinazolinone, 2-Amino-5-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block characterized by its quinazolinone core and trifluoromethyl substituent. This compound is essential for advanced research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for developing potential kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinazolinone scaffold.
• Material Science: Serves as a precursor for advanced organic electronic materials and functional dyes.
• Academic & Contract Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Fluorinated Compound Synthesis: The trifluoromethyl group makes it a valuable fluorinated building block for creating compounds with improved lipophilicity and bioavailability.

Basic Information

Product Name	4(3H)-Quinazolinone, 2-Amino-5-(Trifluoromethyl)-
CAS No.	133116-85-5
Molecular Formula	C9H6F3N3O
Molecular Weight	229.16 g/mol
Synonyms	2-Amino-5-(trifluoromethyl)quinazolin-4(3H)-one; 2-Amino-5-(trifluoromethyl)-4(3H)-quinazolinone; 5-(Trifluoromethyl)-2-amino-4(3H)-quinazolinone; 2-Amino-5-trifluoromethyl-3H-quinazolin-4-one; AQT; 2-Amino-5-CF3-quinazolin-4-one; 133116-85-5
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-5-(Trifluoromethyl)-4(3H)-quinazolinone is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) including HPLC purity, identity confirmation (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.