Description

1-Bromo-3-(2-Fluoro-Ethoxy)-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique molecular architecture, which combines a bromo substituent for cross-coupling reactions with a fluoroethoxy side chain that can modulate the physicochemical properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials. Its precise structure makes it a critical intermediate for constructing complex molecules where specific electronic and steric characteristics are required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of specialty chemicals for electronic displays, leveraging its aromatic and fluorinated components to tune electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs as a versatile reagent for exploring new synthetic methodologies and creating novel molecular libraries.
• Fluorine Chemistry Studies: Acts as a model compound for studying the influence of fluoroalkoxy groups on aromatic system reactivity and interaction.

Basic Information

Product Name	1-Bromo-3-(2-Fluoro-Ethoxy)-Benzene
CAS No.	132837-02-6
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	3-Bromo-1-(2-fluoroethoxy)benzene; 1-Bromo-3-(2-fluoroethoxy)benzene; 2-Fluoroethyl 3-bromophenyl ether; m-Bromo(2-fluoroethoxy)benzene; Benzene, 1-bromo-3-(2-fluoroethoxy)-; 3-(2-Fluoroethoxy)bromobenzene; 3-Bromophenyl 2-fluoroethyl ether
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(2-Fluoro-Ethoxy)-Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting the exact specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.