Description

3,5-Difluoromandelic Acid is a fluorinated derivative of mandelic acid, serving as a versatile chiral building block and intermediate in advanced organic synthesis. Its value lies in the introduction of fluorine atoms at strategic positions, which can significantly alter the electronic properties, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluoromandelic acid moiety contributes to biological activity.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Serves as a precursor for other specialty fluorinated compounds and fine chemicals.
• Biochemical Research: Utilized in proteomics and enzyme inhibition studies as a probe or inhibitor scaffold.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with unique properties.

Basic Information

Product Name	3,5-Difluoromandelic Acid
CAS No.	132741-31-2
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	(3,5-Difluorophenyl)(hydroxy)acetic acid; 2-Hydroxy-2-(3,5-difluorophenyl)acetic acid; DL-3,5-Difluoromandelic acid; α-Hydroxy-3,5-difluorobenzeneacetic acid; 3,5-Difluorobenzene glycolic acid; Mandelic acid, 3,5-difluoro-; 3,5-Difluoro-α-hydroxybenzeneacetic acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoromandelic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.