Description

4-Chloro-Quinoline-8-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industrial and research chemists need it for constructing active pharmaceutical ingredients (APIs), functional materials, and specialized ligands due to its reactive chloro and cyano substituents.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of novel quinoline-based drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the bioactivity of the quinoline core.
• Material Science: Serves as a building block for organic semiconductors, light-emitting diodes (OLEDs), and other functional organic materials.
• Coordination Chemistry: Acts as a versatile ligand precursor for metal-organic frameworks (MOFs) and catalytic complexes.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex functionalities.
• Academic & R&D: A valuable reagent for methodological studies and the exploration of new synthetic pathways in heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-Quinoline-8-Carbonitrile
CAS No.	132664-40-5
Molecular Formula	C10H5ClN2
Molecular Weight	188.61 g/mol
Synonyms	8-Cyano-4-chloroquinoline; 4-Chloro-8-cyanoquinoline; 4-Chloroquinoline-8-carbonitrile; Quinoline, 4-chloro-8-cyano-; 132664-40-5; 4-Chloro-8-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-Quinoline-8-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.