Description

(R)-2-(Aminomethyl)-4-Methylpentanoic Acid-Hcl CAS NO 132605-95-9 is a high-purity chiral amino acid derivative, specifically the hydrochloride salt of the (R)-enantiomer. This compound is a critical building block in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs), where stereochemical purity is paramount. It is primarily utilized by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel APIs, particularly in peptide and peptidomimetic drug discovery.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereocenters.
• Biochemical Research: Used in enzymology studies and as a substrate or inhibitor for specific enzymes.
• Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships (SAR) or to create modified peptide sequences.
• Ligand Development: Utilized in the design and synthesis of chiral ligands for catalysis or molecular recognition.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(R)-2-(Aminomethyl)-4-Methylpentanoic Acid Hydrochloride
CAS No.	132605-95-9
Molecular Formula	C7H15NO2 • HCl
Molecular Weight	197.66 g/mol
Synonyms	(R)-2-(Aminomethyl)-4-methylpentanoic acid hydrochloride; (R)-HomoLeucine HCl; D-HomoLeucine hydrochloride; (R)-2-Amino-4-methylhexanoic acid hydrochloride (deprecated); (2R)-2-(Aminomethyl)-4-methylpentanoic acid hydrochloride; (R)-2-(Aminomethyl)-4-methylvaleric acid hydrochloride; (R)-α-Amino-ε-methylcaproic acid hydrochloride
EINECS	Contact for details

Quality Control

Our production of (R)-2-(Aminomethyl)-4-Methylpentanoic Acid-Hcl adheres to stringent quality management systems. Each batch is characterized and tested to ensure high chemical and enantiomeric purity, meeting the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Comprehensive analytical data, including HPLC for purity and chiral assay, is documented in a batch-specific Certificate of Analysis (COA), which is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.