Description

Dirhodium (II) Tetrakis(Methyl 2-Pyrrolidone-5(S)-Carboxylate)Acetonitrile/2-Propanol Complex is a highly specialized chiral dirhodium catalyst, distinguished by its unique paddlewheel structure and ligand framework. This compound is critical for enabling highly enantioselective and efficient carbon-hydrogen (C-H) functionalization and cyclopropanation reactions, which are cornerstone transformations in modern synthetic organic chemistry. It is an essential tool for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to construct complex, optically active molecules with high precision.

Application

• Asymmetric C-H Amination: A premier catalyst for the enantioselective insertion of nitrenes into C-H bonds to create chiral amines, key intermediates in active pharmaceutical ingredients (APIs).
• Enantioselective Cyclopropanation: Enables the synthesis of chiral cyclopropane rings, a privileged structural motif found in many bioactive compounds and agrochemicals.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly for constructing stereogenic centers with high enantiomeric excess.
• Fine Chemical and Fragrance Manufacturing: Facilitates the production of high-value, optically pure specialty chemicals and aroma compounds.
• Methodology Development in Academia: A valuable reagent for university and institutional research groups exploring new catalytic asymmetric transformations.
• Process Chemistry Optimization: Employed in scaling up asymmetric reactions from laboratory to pilot plant scale for commercial production.

Basic Information

Product Name	Dirhodium (II) Tetrakis(Methyl 2-Pyrrolidone-5(S)-Carboxylate)Acetonitrile/2-Propanol Complex
CAS No.	132435-65-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Dirhodium(II) tetrakis[methyl (5S)-2-oxo-5-pyrrolidinecarboxylate] acetonitrile/isopropanol complex; Rh₂(S-MEPY)₄; Dirhodium(II) (S)-methyl 2-pyrrolidone-5-carboxylate complex; Chiral Dirhodium Catalyst Rh₂(S-MEPY)₄; Dirhodium tetrakis[(S)-N-(methoxycarbonyl)-2-pyrrolidinonate] acetonitrile/isopropanol adduct
EINECS	Contact for details

Quality Control

Every batch of our chiral dirhodium catalysts is produced and tested under strict quality management protocols to ensure exceptional lot-to-lot consistency and catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as Rhodium content, enantiomeric purity of the ligand, and solvent composition. Our quality commitment aligns with the standards required for GMP-ready intermediate synthesis and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Dark green to purple crystalline solid or powder
Identification (IR)	Conforms to structure
Rhodium (Rh) Content	Contact for details
Assay (HPLC)	≥ 95% (Area %)
Solvent Content (NMR)	Acetonitrile and 2-Propanol as per stoichiometry
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.