Description

α-Amino-1,2-Dihydro-2-Oxo-4-Quinolinepropanoic Acid Hydrochloride is a high-purity, non-natural amino acid derivative with a quinoline core, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its primary value lies in enabling the construction of complex molecules for pharmaceutical research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents or specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel drug candidates, particularly in oncology, neurology, and anti-infective therapeutic areas.
• Peptidomimetics & Constrained Peptide Design: Used to incorporate rigid, planar quinoline structures into peptide backbones to enhance metabolic stability and receptor binding affinity.
• Organocatalyst & Ligand Precursor: Serves as a precursor for synthesizing specialized chiral catalysts and ligands used in asymmetric synthesis.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and plant growth regulators with unique modes of action.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Academic & Institutional Research: Fundamental building block for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	α-Amino-1,2-Dihydro-2-Oxo-4-Quinolinepropanoic Acid Hydrochloride
CAS No.	132210-25-4
Molecular Formula	C₁₂H₁₃N₂O₃·HCl
Molecular Weight	268.70 g/mol (Free base: 233.25 g/mol)
Synonyms	4-Quinolinepropanoic acid, α-amino-1,2-dihydro-2-oxo-, hydrochloride; (S)-2-Amino-3-(1,2-dihydro-2-oxo-4-quinolinyl)propanoic acid hydrochloride; 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride; L-2-Amino-3-(1,2-dihydro-2-oxo-4-quinolyl)propionic acid HCl; 132210-25-4; Quinoline amino acid hydrochloride derivative
EINECS	Contact for details

Quality Control

Our α-Amino-1,2-Dihydro-2-Oxo-4-Quinolinepropanoic Acid Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation and clumping. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.