Description

4-Chloro-3H-Imidazo[4,5-C]Quinoline is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block of significant commercial and research interest. Its unique fused-ring structure makes it a critical precursor in the synthesis of novel therapeutic agents, particularly in the fields of oncology and immunology. This compound is essential for medicinal chemistry research, process development, and the manufacturing of active pharmaceutical ingredients (APIs) targeting global health challenges.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of Toll-like receptor (TLR) agonists and other immunomodulatory drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for developing new small-molecule therapeutics.
• Oncology Drug Development: Serves as a core scaffold in the research and production of investigational anti-cancer compounds.
• Biochemical Research: Employed as a tool compound in immunological assays and pathway studies.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and cGMP manufacturing of clinical trial materials.
• Custom Synthesis: A starting material for the preparation of more complex, functionalized imidazoquinoline derivatives.

Basic Information

Product Name	4-Chloro-3H-Imidazo[4,5-C]Quinoline
CAS No.	132206-92-9
Molecular Formula	C10H6ClN3
Molecular Weight	203.63 g/mol
Synonyms	4-Chloro-1H-imidazo[4,5-c]quinoline; 4-Chloroimidazo[4,5-c]quinoline; 132206-92-9; TLR7/8 Agonist Intermediate; Imiquimod-related intermediate; 1H-Imidazo[4,5-c]quinoline, 4-chloro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3H-Imidazo[4,5-C]Quinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.