Description

2-(Trifluoromethyl)Isonicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoromethyl group and the carboxylic acid functionality, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to incorporate fluorinated motifs into active molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic components.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biomolecules for metabolic studies, imaging, and probing enzyme mechanisms.

Basic Information

Product Name	2-(Trifluoromethyl)Isonicotinic Acid
CAS No.	131747-41-6
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	2-(Trifluoromethyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-(trifluoromethyl)-; Isonicotinic acid, 2-(trifluoromethyl)-; 2-Trifluoromethylisonicotinic acid; 2-CF3-Isonicotinic Acid; 2-(Trifluoromethyl)-4-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.