Description

Chloro[(R)-(+)-2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl](p-Cymene)Ruthenium(II) Chloride is a high-value, chiral ruthenium complex widely recognized as a highly efficient asymmetric hydrogenation catalyst. Its primary value lies in enabling the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with exceptional selectivity and yield. This catalyst is essential for R&D and manufacturing chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to establish robust and scalable chiral synthesis routes.

Application

• Asymmetric Hydrogenation Catalysis: Key catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for manufacturing chiral building blocks and active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Synthesis: Enables the production of high-value chiral compounds for flavors, fragrances, and specialty materials.
• Academic and Industrial R&D: A benchmark catalyst for method development and exploring new asymmetric transformations in process chemistry.
• Process Scale-up and Optimization: Employed in kilo-lab and pilot plant operations to transfer and optimize chiral synthesis from laboratory to commercial scale.

Basic Information

Product Name	Chloro[(R)-(+)-2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl](p-Cymene)Ruthenium(II) Chloride
CAS No.	131614-43-2
Molecular Formula	C61H52Cl2P2Ru
Molecular Weight	1010.90 g/mol
Synonyms	(R)-RuCl(p-cymene)(DTBINAP); (R)-[RuCl(p-cymene)(DTBINAP)]Cl; (R)-RuCl(η6-p-cymene)(DTBINAP) Chloride; (R)-DTBINAP-Ru(p-cymene)Cl Chloride; (R)-Ru(DTBINAP)(p-cymene)Cl2; (R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl(p-cymene)ruthenium(II) dichloride; RuCl[(R)-DTBINAP](p-cymene)Cl
EINECS	Contact for details

Quality Control

Every batch of our Chloro[(R)-(+)-2,2'-Bis(Di-p-Tolylphosphino)-1,1'-Binaphthyl](p-Cymene)Ruthenium(II) Chloride is manufactured and tested under strict quality management systems to ensure consistent catalytic performance and high chemical purity. Our standard quality protocol includes comprehensive analysis to confirm identity, purity, and chiral integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, enantiomeric purity, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use and handled in a controlled, dry environment.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity	≥ 99.0% ee (by chiral HPLC)
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.