Description

H-D-Pro-Oet Hcl is a high-purity, non-natural amino acid derivative widely used as a critical chiral building block in advanced organic synthesis. This compound is essential for introducing the unique conformational constraints of the proline scaffold into target molecules, significantly influencing their biological activity and stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds. Our supply ensures consistent quality and reliable availability for your most demanding synthesis projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate D-proline derivatives, modifying peptide stability and receptor binding.
• Medicinal Chemistry Research: Serves as a constrained scaffold in drug discovery for creating novel pharmacophores and probing structure-activity relationships (SAR).
• Bioconjugation: Can be utilized in the synthesis of labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Catalyst & Ligand Synthesis: Acts as a precursor for chiral catalysts or ligands used in asymmetric synthesis.
• Academic & Industrial R&D: Employed in chemical biology studies and the development of new synthetic methodologies.

Basic Information

Product Name	H-D-Pro-Oet Hcl
CAS No.	131477-20-8
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	D-Proline, ethyl ester, hydrochloride; Ethyl D-prolinate hydrochloride; (R)-(-)-Proline ethyl ester hydrochloride; H-D-Pro-OEt·HCl; D-Pro-OEt·HCl; Ethyl (R)-(-)-2-pyrrolidinecarboxylate hydrochloride; (R)-1-Carbethoxy-2-pyrrolidine hydrochloride; UNII-5Q4K0P8T1F
EINECS	Contact for details

Quality Control

Every batch of H-D-Pro-Oet Hcl is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as chiral purity, chemical purity, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.