Description

7-Chloro-8-Hydroxy-1-(4'-Formylphenyl)-3-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine is a sophisticated benzazepine derivative, a key chemical building block prized for its unique molecular architecture. Its core value lies in serving as a critical advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. This compound is essential for medicinal chemistry programs targeting central nervous system (CNS) disorders and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Primary use as a key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for CNS-targeting drugs.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery pipelines.
• Chemical Synthesis: Utilized in organic synthesis for constructing complex heterocyclic compounds due to its reactive formyl and hydroxy functional groups.
• Biochemical Research: Potential use as a ligand or probe in biochemical assays to study receptor interactions and enzyme inhibition.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for custom synthesis projects under cGMP conditions.
• Academic Research: Used in university and institutional laboratories for advanced organic chemistry and pharmacology studies.

Basic Information

Item	Details
Product Name	7-Chloro-8-Hydroxy-1-(4'-Formylphenyl)-3-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine
CAS No.	131275-92-8
Molecular Formula	C19H18ClNO2
Molecular Weight	327.80 g/mol
Synonyms	1-(4-Formylphenyl)-7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7-Chloro-8-hydroxy-1-(4-formylphenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 1-(4'-Formylphenyl)-7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; Benzazepine derivative CAS 131275-92-8; 3-Benzazepine-1-carboxaldehyde, 7-chloro-2,3,4,5-tetrahydro-8-hydroxy-3-methyl-1-(4-formylphenyl)-
EINECS	Contact for details

Quality Control

Our 7-Chloro-8-Hydroxy-1-(4'-Formylphenyl)-3-Methyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment. We support development under cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.