Description

1H-Pyrrole-2,5-Dione, 1-[2-(2-Aminoethoxy)Ethyl]-, 2,2,2-Trifluoroacetate (1:1) is a high-purity specialty chemical building block, primarily recognized as a protected amine derivative of a maleimide functional group. This compound is critical for researchers and manufacturers requiring precise molecular conjugation and controlled reactivity in advanced synthesis. It is particularly valuable for the development of pharmaceuticals, bioconjugates, and sophisticated polymer materials where site-specific functionalization is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring maleimide-thiol click chemistry for targeted drug delivery systems.
• Bioconjugation Reagent: Used for the site-specific labeling and crosslinking of proteins, antibodies, and peptides in diagnostic assay development and biotherapeutic production.
• Polymer Science: Acts as a functional monomer or crosslinking agent in the production of specialty polymers, hydrogels, and smart materials with responsive properties.
• Chemical Biology Research: Enables the study of protein interactions, cellular pathways, and the development of novel probes and inhibitors in academic and industrial R&D settings.
• ADC (Antibody-Drug Conjugate) Development: A crucial component in the linker-payload chemistry for constructing next-generation ADCs, a rapidly growing class of targeted cancer therapies.
• Material Surface Modification: Facilitates the covalent attachment of bioactive molecules to surfaces for applications in biosensors, medical devices, and chromatography media.

Basic Information

Item	Details
Product Name	1H-Pyrrole-2,5-Dione, 1-[2-(2-Aminoethoxy)Ethyl]-, 2,2,2-Trifluoroacetate (1:1)
CAS No.	131274-17-4
Molecular Formula	C10H11F3N2O5
Molecular Weight	296.20 g/mol
Synonyms	N-(2-(2-Aminoethoxy)ethyl)maleimide trifluoroacetate; 2,5-Dioxo-1-pyrrolidinyl-2-(2-aminoethoxy)ethyl Trifluoroacetate; Maleimide-PEG2-amine TFA salt; 1-[2-(2-Aminoethoxy)ethyl]-1H-pyrrole-2,5-dione trifluoroacetate; N-(2-(2-Aminoethoxy)ethyl)maleimide TFA; Amine-PEG2-maleimide TFA; TFA salt of N-(2-(2-Aminoethoxy)ethyl)maleimide
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrrole-2,5-Dione, 1-[2-(2-Aminoethoxy)Ethyl]-, 2,2,2-Trifluoroacetate (1:1) is manufactured and tested under a strict quality management system. We ensure compliance with high-purity research and pharmaceutical-grade standards. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and meet your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.