Description

Fmoc-Dap(Boc)-Oh CAS NO 130851-23-9 is a high-purity, orthogonally protected derivative of 2,3-diaminopropionic acid (Dap), specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique Dap amino acid into peptide chains, enabling the creation of complex structures for advanced research and therapeutic development. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies focused on developing novel peptide-based drugs, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the controlled incorporation of 2,3-diaminopropionic acid into peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including antimicrobial peptides (AMPs), enzyme inhibitors, and hormone analogs.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by allowing precise modification at the β-amino position of the Dap side chain.
• Bioconjugation and Linker Chemistry: The orthogonal Fmoc and Boc protecting groups enable selective deprotection for creating branched peptides or attaching labels, tags, or other functional molecules.
• Combinatorial Library Synthesis: A valuable reagent for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: Employed in the study of protein-protein interactions, enzyme mechanisms, and the development of biochemical probes.

Basic Information

Product Name	Fmoc-Dap(Boc)-Oh
CAS No.	130851-23-9
Molecular Formula	C24H28N2O6
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-Dap(Boc)-OH; Nα-Fmoc-Nβ-Boc-L-2,3-diaminopropionic acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; Fmoc-L-Dap(Boc)-OH; Fmoc-Dap(Boc); Boc-Dap(Fmoc)-OH; Nα-Fmoc-Nβ-Boc-Dap-OH; Fmoc-2,3-diaminopropionic acid(Boc)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Dap(Boc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.