Description

Niravoline CAS NO 130610-93-4 is a selective κ-opioid receptor antagonist with significant research and therapeutic potential. This compound is of critical importance for its role in modulating diuretic and antidiuretic effects, making it a valuable tool for studying renal function and water balance. It is primarily needed by pharmaceutical R&D teams, academic researchers, and clinical investigators focused on developing treatments for conditions related to fluid retention, hyponatremia, and central nervous system disorders.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate for investigating κ-opioid receptor pathways.
• Diuretic/Antidiuretic Studies: Central to preclinical and clinical research aimed at understanding and managing body water homeostasis and related disorders.
• Neuropharmacology: Used in studies exploring the central nervous system effects of opioid receptor modulation, including potential applications in pain and addiction research.
• Clinical Trial Material: Serves as a critical component in the synthesis and formulation of drug candidates for Phase I-III clinical trials.
• Biochemical Assay Development: Employed as a ligand in receptor binding assays and other in vitro tests to screen for biological activity.
• Academic & Institutional Research: Provides a reliable chemical tool for universities and research institutes studying renal physiology and opioid receptor pharmacology.

Basic Information

Product Name	Niravoline
CAS No.	130610-93-4
Molecular Formula	C23H30N2O3
Molecular Weight	382.50 g/mol
Synonyms	RU 51599; (2S)-2-[(1R,9R,10S)-12-(Cyclopropylmethyl)-7,10-dihydroxy-1,2,3,4,5,6-hexahydro-6,10-methano-8H-isoquinolino[2,1-g][1,6]naphthyridin-9-yl]-N-ethyl-2-hydroxyacetamide; (+)-Niravoline; (S)-(+)-Niravoline; Niravoline (RU-51599)
EINECS	Contact for details

Quality Control

Every batch of Niravoline is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.