Description

3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzoic Acid is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique halogenated structure, featuring chlorine, fluorine, and a trifluoromethyl group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for developing novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated benzoic acid motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorine-containing liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the synthesis of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A valuable reagent for medicinal chemistry, process chemistry, and exploring new synthetic methodologies in academic and industrial labs.

Basic Information

Product Name	3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzoic Acid
CAS No.	129931-45-9
Molecular Formula	C8H3ClF4O2
Molecular Weight	242.56 g/mol
Synonyms	3-Chloro-2-fluoro-5-(trifluoromethyl)benzoic acid; 2-Fluoro-3-chloro-5-(trifluoromethyl)benzoic acid; Benzoic acid, 3-chloro-2-fluoro-5-(trifluoromethyl)-; 129931-45-9; 3-Chloro-2-fluoro-alpha,alpha,α-trifluoro-m-toluic acid; 5-(Trifluoromethyl)-3-chloro-2-fluorobenzoic acid; 2-Fluoro-3-chloro-α,α,α-trifluoro-m-toluic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its fluoride/strong alkali sensitivity, ensure the container is kept tightly sealed and stored separately from reactive substances.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.