Description

2-Methyl-4-(Trifluoromethoxy)Phenol (CAS NO 129676-67-1) is a high-value fluorinated phenolic intermediate characterized by its trifluoromethoxy and methyl substituents on the aromatic ring. This unique structure imparts enhanced lipophilicity, metabolic stability, and electronic properties, making it a critical building block for advanced chemical synthesis. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated compounds used in electronic displays, leveraging its stable aromatic core and fluorine content.
• Polymer Modification: Acts as a functional monomer or additive to introduce fluorine into polymer chains, improving material properties like chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, etherifications, and other transformations to create complex, fluorinated molecules for material science and chemical research.

Basic Information

Product Name	2-Methyl-4-(Trifluoromethoxy)Phenol
CAS No.	129676-67-1
Molecular Formula	C8H7F3O2
Molecular Weight	192.14 g/mol
Synonyms	4-(Trifluoromethoxy)-2-methylphenol; 2-Methyl-4-(trifluoromethoxy)phenol; 2-Methyl-4-trifluoromethoxyphenol; 4-Hydroxy-3-methylphenyl trifluoromethyl ether; 3-Methyl-4-hydroxyphenyl trifluoromethyl ether; o-Cresol, 4-(trifluoromethoxy)-; Phenol, 2-methyl-4-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-4-(Trifluoromethoxy)Phenol adheres to a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee it meets your precise R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.