Description

Spiro[2-Azabicyclo[2.2.1]Heptane-7,1-Cyclopropane] (9Ci) is a structurally complex and synthetically valuable spirocyclic amine building block. This compound is of significant interest in advanced pharmaceutical research and development due to its rigid, three-dimensional framework, which is crucial for modulating the biological activity and pharmacokinetic properties of drug candidates. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of central nervous system (CNS) active drugs, protease inhibitors, and other therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its unique structure can impart specific biological activity.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or building block for advanced polymers with specific thermal or mechanical properties.
• Academic & Contract Research: Essential for methodological development and novel synthetic route exploration in university and CRO laboratories.

Basic Information

Product Name	Spiro[2-Azabicyclo[2.2.1]Heptane-7,1-Cyclopropane] (9Ci)
CAS No.	129449-29-2
Molecular Formula	C8H13N
Molecular Weight	123.20 g/mol
Synonyms	7-Azaspiro[2.5]octane; 2-Azabicyclo[2.2.1]heptane, spirocyclopropane derivative; 1-Azaspiro[2.5]octane; Spiro[cyclopropane-1,7'-[2]azabicyclo[2.2.1]heptane]; 129449-29-2; 7-Aza-spiro[2.5]octane; NSC 405124; Spiro(cyclopropane-1,7'-[2]azabicyclo[2.2.1]heptane)
EINECS	Contact for details

Quality Control

Every batch of Spiro[2-Azabicyclo[2.2.1]Heptane-7,1-Cyclopropane] (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for critical R&D and scale-up activities. A detailed Certificate of Analysis (COA) including results from GC, HPLC, NMR, and other relevant analyses is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.