Description

N,n-Dimethyl-2-(tert-Butyldimethylsilanyl)Imidazole-1-Sulfonamide is a specialized organosilicon-protected sulfonamide derivative, serving as a critical synthetic intermediate and protecting group reagent in advanced organic synthesis. Its value lies in its ability to impart steric bulk and stability to sensitive functional groups, enabling complex multi-step reactions with high selectivity and yield. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those containing imidazole or sulfonamide pharmacophores.
• Protecting Group Reagent: Used to temporarily mask reactive amine or hydroxyl groups during complex multi-step synthetic sequences, leveraging the tert-butyldimethylsilyl (TBDMS) group's stability.
• Agrochemical Synthesis: Intermediate in the production of advanced pesticides and herbicides requiring specific heterocyclic frameworks.
• Organic Synthesis Research: A valuable tool for academic and industrial R&D labs exploring new reaction methodologies and constructing complex molecular architectures.
• Material Science Precursor: Potential use in the development of specialty polymers or surface-modifying agents where silicon-containing moieties are beneficial.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial production of fine chemicals.

Basic Information

Product Name	N,n-Dimethyl-2-(tert-Butyldimethylsilanyl)Imidazole-1-Sulfonamide
CAS No.	129378-52-5
Molecular Formula	C11H23N3O2SSi
Molecular Weight	289.48 g/mol
Synonyms	1-[(1,1-Dimethylethyl)dimethylsilyl]-N,N-dimethyl-1H-imidazole-1-sulfonamide; 2-(tert-Butyldimethylsilyl)-N,N-dimethylimidazole-1-sulfonamide; TBDMS-Protected Imidazole Sulfonamide; N,N-Dimethyl-2-[(tert-butyldimethylsilyl)]imidazole-1-sulfonamide; 1H-Imidazole-1-sulfonamide, 1-[(1,1-dimethylethyl)dimethylsilyl]-N,N-dimethyl-; 129378-52-5; N,N-Dimethyl-2-(tert-butyldimethylsilyl)imidazole-1-sulfonamide
EINECS	Contact for details

Quality Control

Our N,n-Dimethyl-2-(tert-Butyldimethylsilanyl)Imidazole-1-Sulfonamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.