Description

(2S,3S)-2-(Bromomethyl)-3-Chloro-Oxirane CAS NO 129176-04-1 is a high-purity, chiral epoxide building block of significant interest in advanced organic synthesis. Its unique stereochemistry and bifunctional halogenated structure make it a versatile precursor for constructing complex, optically active molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those requiring specific stereocenters.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where its reactive epoxide and halogen groups enable further functionalization.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Can be employed to introduce reactive sites or chiral elements into polymer backbones for specialty materials.
• Cross-coupling Reactions: The bromomethyl group makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Academic and Industrial R&D: A valuable tool for methodological studies in organic chemistry and the discovery of new synthetic pathways.

Basic Information

Product Name	(2S,3S)-2-(Bromomethyl)-3-Chloro-Oxirane
CAS No.	129176-04-1
Molecular Formula	C4H6BrClO
Molecular Weight	185.45 g/mol
Synonyms	(2S,3S)-2-(Bromomethyl)-3-chlorooxirane; (2S,3S)-3-Chloro-2-(bromomethyl)oxirane; (-)-(2S,3S)-Epibromohydrin; (2S,3S)-Epibromohydrin; (2S,3S)-1-Bromo-3-chloro-2,3-epoxypropane; (2S,3S)-1-Chloro-3-bromo-2,3-epoxypropane; Chiral Epibromohydrin; (2S,3S)-2-Bromomethyl-3-chlorooxirane
EINECS	Contact for details

Quality Control

Our production of (2S,3S)-2-(Bromomethyl)-3-Chloro-Oxirane adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its reactive nature and sensitivity to light and moisture, it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.