Description

(2S,6S,8S,11S)-1,10-Diazatricyclo[6.4.01,8.02.6]Dodecan-9,12-Dione is a sophisticated, high-purity chiral bicyclic diamide compound with a complex, rigid molecular architecture. This compound matters as a critical advanced pharmaceutical intermediate and a versatile chiral building block for asymmetric synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) with high stereochemical fidelity. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors engaged in the synthesis of complex molecules, particularly those requiring specific stereochemistry for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalysis Ligand Precursor: Serves as a foundational structure for developing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Used in the research and development of new, stereochemically-defined pesticides and herbicides where specific isomer activity is crucial.
• Advanced Material Science: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties due to its rigid, polycyclic core.
• Academic & Process Chemistry: A valuable compound for methodological studies in organic synthesis, including studies on ring-closing reactions and stereocontrol.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	(2S,6S,8S,11S)-1,10-Diazatricyclo[6.4.01,8.02.6]Dodecan-9,12-Dione
CAS No.	129048-16-4
Molecular Formula	C10H14N2O2
Molecular Weight	194.23 g/mol
Synonyms	(2S,6S,8S,11S)-1,10-Diazatricyclo[6.4.0.01,8.02,6]dodecane-9,12-dione; (2S,6S,8S,11S)-1,10-Diazatricyclo[6.4.01,8.02,6]dodecane-9,12-dione; 1,10-Diazatricyclo[6.4.01,8.02,6]dodecane-9,12-dione, (2S,6S,8S,11S)-; Bicyclic Diamide Derivative; Chiral Bicyclic Lactam; (all-S)-1,10-Diazatricyclo[6.4.0.0¹,⁸.0²,⁶]dodecane-9,12-dione
EINECS	Contact for details

Quality Control

Our (2S,6S,8S,11S)-1,10-Diazatricyclo[6.4.01,8.02.6]Dodecan-9,12-Dione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical assay, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.