Description

3-(tert-Butoxycarbonyl)-1-Methyl-1H-Pyrazole-5-Carboxylic Acid is a high-purity, protected pyrazole carboxylic acid derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and other heterocyclic-based therapeutic programs.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the pyrazole core's bioactivity.
• Peptide Mimetics & Conjugates: Serves as a protected carboxylic acid handle for coupling reactions to create peptide-like structures or drug-linker components.
• Material Science: Potential monomer or functionalization agent for creating specialized polymers with unique properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Item	Details
Product Name	3-(tert-Butoxycarbonyl)-1-Methyl-1H-Pyrazole-5-Carboxylic Acid
CAS No.	128883-83-0
Molecular Formula	C11H16N2O4
Molecular Weight	240.26 g/mol
Synonyms	1-Methyl-3-(Boc)-1H-pyrazole-5-carboxylic acid; 1-Methyl-3-[(2-methyl-2-propanyl)oxycarbonyl]-1H-pyrazole-5-carboxylic acid; 5-Carboxy-1-methyl-3-Boc-pyrazole; tert-Butyl 5-carboxy-1-methyl-1H-pyrazole-3-carboxylate; 3-Boc-1-methyl-1H-pyrazole-5-carboxylic acid; Boc-1-Me-Pyz-5-COOH; 1-Methyl-1H-pyrazole-3,5-dicarboxylic acid 3-tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of 3-(tert-Butoxycarbonyl)-1-Methyl-1H-Pyrazole-5-Carboxylic Acid is produced under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent exposure to atmospheric moisture, which can lead to degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.