Description

Ethanone, 2-Chloro-1-(4-Hydroxycyclohexyl)-, cis- (9Ci) is a specialized organic intermediate featuring a unique cyclohexanol backbone substituted with a chloroacetyl group. This compound matters for its role as a key chiral building block in the synthesis of complex pharmaceutical molecules and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific stereochemistry and functional groups into their target compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides where the specific stereochemistry influences biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of chiral dopants and charge-transport materials for electronic displays.
• Asymmetric Catalysis Ligand Precursor: Provides a scaffold for developing novel chiral ligands used in enantioselective synthesis.
• Fine Chemical & Flavor/Fragrance Intermediate: Employed in the multi-step synthesis of complex natural product analogs and specialty aroma chemicals.
• Academic & Contract Research: A valuable reagent for methodological studies in organic synthesis and medicinal chemistry within academic and CRO settings.

Basic Information

Product Name	Ethanone, 2-Chloro-1-(4-Hydroxycyclohexyl)-, cis- (9Ci)
CAS No.	128882-60-0
Molecular Formula	C8H13ClO2
Molecular Weight	176.64 g/mol
Synonyms	2-Chloro-1-(4-hydroxycyclohexyl)ethanone, cis-; cis-2-Chloro-1-(4-hydroxycyclohexyl)ethanone; 1-(4-Hydroxycyclohexyl)-2-chloroethanone; (cis)-2-Chloro-1-(4-hydroxycyclohexyl)ethan-1-one; 4-Hydroxycyclohexyl chloromethyl ketone; Chloro-(4-hydroxycyclohexyl)methyl ketone; 128882-60-0; cis-4-Hydroxycyclohexyl chloromethyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 2-Chloro-1-(4-Hydroxycyclohexyl)-, cis- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability, consistency, and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.