Description

Thp-Peg5 is a specialized polyethylene glycol (PEG) derivative featuring a tetrahydropyranyl (THP) protecting group. This bifunctional molecule is engineered to serve as a versatile linker and spacer in advanced organic synthesis and bioconjugation. It is particularly valuable for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require controlled, site-specific modifications of active molecules. The product is supplied under the identifier CAS No. 128660-97-9.

Application

• Pharmaceutical Intermediates: Acts as a key building block and hydrophilic spacer in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutics.
• Bioconjugation & PEGylation: Used to modify peptides, proteins, and oligonucleotides to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Polymer Chemistry: Serves as a functional initiator or monomer for creating specialized block copolymers and hydrogels with tailored properties.
• Material Science: Employed in surface functionalization and the development of smart materials and drug delivery systems like micelles and nanoparticles.
• Cross-linking Agent: Utilized in the preparation of biodegradable matrices and scaffolds for tissue engineering applications.
• Chemical Probes: Functions as a linker in the development of diagnostic reagents and imaging agents.

Basic Information

Product Name	Thp-Peg5
CAS No.	128660-97-9
Molecular Formula	C22H44O9
Molecular Weight	452.59 g/mol
Synonyms	2-(2-(2-(2-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol; THP-PEG5-OH; Tetrahydropyranyl-PEG5-alcohol; 3,6,9,12,15-Pentaoxaheptacosan-27-ol, 2-(tetrahydro-2H-pyran-2-yloxy)-; PEG5 THP Ether; THP-protected pentaethylene glycol; 2-[2-[2-[2-[2-(Oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
EINECS	Contact for details

Quality Control

Our Thp-Peg5 is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.