Description

(R)-2-Hydroxy-4-Phenylbutenoic Acid is a chiral, non-proteinogenic hydroxy acid that serves as a valuable synthetic intermediate. Its significance lies in its role as a key building block for the synthesis of pharmaceuticals and fine chemicals, particularly those requiring a specific stereochemical configuration. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of angiotensin-converting enzyme (ACE) inhibitors and other cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of chiral herbicides and plant growth regulators.
• Fine Chemical Building Block: Employed in asymmetric synthesis for creating complex natural products and specialty polymers.
• Catalyst and Ligand Development: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis.
• Biochemical Research: Used in studies of enzyme mechanisms and as a standard in analytical method development.
• Flavor and Fragrance Industry: Potential intermediate for the synthesis of specific chiral aroma compounds.

Basic Information

Product Name	(R)-2-Hydroxy-4-Phenylbutenoic Acid
CAS No.	128573-54-6
Molecular Formula	C10H10O3
Molecular Weight	178.18 g/mol
Synonyms	(R)-2-Hydroxy-4-phenyl-2-butenoic acid; (2R)-2-Hydroxy-4-phenylbut-3-enoic acid; (R)-Hpba; (R)-2-Hydroxy-4-phenyl-3-butenoic acid; (R)-4-Phenyl-2-hydroxy-2-butenoic acid; (2R)-Hydroxy-4-phenyl-3-butenoic acid; (R)-α-Hydroxy-β-vinylbenzenepropanoic acid
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxy-4-Phenylbutenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination, to ensure compliance with customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment. We support development and scale-up with custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.