Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel fluoroquinolone antibiotics, offering a key structural motif for developing potent antimicrobial agents. It is primarily required by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) engaged in the development of next-generation antibacterial therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of new-generation fluoroquinolone antibiotics.
• Antibacterial Drug Research: Used in medicinal chemistry for the design and synthesis of compounds targeting DNA gyrase and topoisomerase IV.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of complex API molecules with broad-spectrum antibacterial activity.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale production for new drug candidates.
• Academic & Institutional Research: Used in university and institutional labs for studying structure-activity relationships (SAR) in antimicrobial agents.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo-
CAS No.	128508-00-9
Molecular Formula	C₁₃H₉F₂NO₃
Molecular Weight	265.22 g/mol
Synonyms	1-Cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 6,8-Difluoro-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid; 1-Cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; PD 161148; PD-161148; Abbott-161148; A fluoroquinolone carboxylic acid intermediate; Quinolone-3-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider conditions under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.