Description

L-7-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a specialized heterocyclic organic compound belonging to the tetrahydroisoquinoline class, serving as a key chiral building block and intermediate in advanced organic synthesis. Its structural framework is highly valuable for constructing complex molecules with potential biological activity. This compound is primarily sought by research and development teams in the pharmaceutical and fine chemical industries. It is particularly relevant for the synthesis of novel drug candidates, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug discovery.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate the rigid, constrained tetrahydroisoquinoline scaffold into peptide analogs to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Chemical Research & Development: Serves as a versatile building block in academic and industrial R&D for exploring new chemical entities and reaction pathways.
• Ligand & Catalyst Development: Potential use in the design of novel chiral ligands for metal-catalyzed transformations.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	L-7-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	128502-56-7
Molecular Formula	C10H11NO3
Molecular Weight	193.20 g/mol
Synonyms	(S)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; L-7-Hydroxy-Tic-OH; 7-Hydroxy-L-Tic; (3S)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, L-; 7-Hydroxy-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 7-OH-L-Tic; H-Tic(7-OH)-OH
EINECS	Contact for details

Quality Control

Our L-7-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.