Description

1-Tosyl-1,4,8,11-Tetraazacyclotetradecane Trihydrochloride is a high-purity, functionalized macrocyclic ligand, a key intermediate in the synthesis of sophisticated metal chelators and radiopharmaceuticals. Its value lies in providing a pre-organized, tosyl-protected cyclam framework, which is essential for the controlled complexation of transition metals and radiometals like copper-64 and gallium-68. This compound is critically needed by research institutions and pharmaceutical developers working on advanced diagnostic imaging agents, targeted radiotherapy, and novel catalysts.

Application

• Radiopharmaceutical Precursor: A crucial building block for synthesizing bifunctional chelators used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Theragnostic Agent Development: Serves as an intermediate in creating compounds for combined diagnostic imaging and targeted radiotherapy (e.g., for prostate cancer).
• Metal Chelator Synthesis: Used to produce advanced macrocyclic ligands for complexing copper (Cu), gallium (Ga), indium (In), and other metals in research and industrial catalysis.
• Bioconjugation Chemistry: The tosyl group allows for further functionalization, enabling conjugation to antibodies, peptides, or other targeting molecules in drug discovery.
• Academic & Industrial Research: Employed in studies of coordination chemistry, supramolecular chemistry, and the development of new sensor materials.
• Catalyst Ligand: Potential use as a precursor for ligands in homogeneous catalysis for organic synthesis.

Basic Information

Product Name	1-Tosyl-1,4,8,11-Tetraazacyclotetradecane Trihydrochloride
CAS No.	128495-29-4
Molecular Formula	C19H35Cl3N4O2S
Molecular Weight	489.92 g/mol
Synonyms	1,4,8,11-Tetraazacyclotetradecane, 1-tosyl-, trihydrochloride; TETA-Ts·3HCl; 1-Tosyl-cyclam trihydrochloride; Ts-Cyclam·3HCl; 1-(4-Methylphenyl)sulfonyl-1,4,8,11-tetraazacyclotetradecane trihydrochloride; 1-Tosyl-1,4,8,11-tetraazacyclotetradecane hydrochloride (1:3); Tosyl-cyclam trihydrochloride; 1,4,8,11-Tetraazacyclotetradecane, 1-(4-methylbenzenesulfonyl)-, trihydrochloride
EINECS	Contact for details

Quality Control

Our 1-Tosyl-1,4,8,11-Tetraazacyclotetradecane Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.