Description

(S)-2,2,2-Trifluoro-1-Phenylethylamine Hcl CAS NO 128404-37-5 is a high-purity chiral amine building block, specifically the hydrochloride salt of the (S)-enantiomer, valued for its trifluoromethyl group which imparts unique metabolic stability and lipophilicity to target molecules. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals where stereochemical purity is critical for biological activity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Incorporated into peptide analogs to improve stability and binding affinity.
• Material Science: Potential monomer or additive for specialty polymers with specific optical or surface properties.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-Phenylethylamine Hydrochloride
CAS No.	128404-37-5
Molecular Formula	C8H9ClF3N
Molecular Weight	211.61 g/mol
Synonyms	(S)-α-(Trifluoromethyl)benzylamine hydrochloride; (S)-1-Phenylethylamine, 2,2,2-trifluoro-, hydrochloride; (S)-2,2,2-Trifluoro-1-phenylethanamine hydrochloride; (S)-TFMPA HCl; (S)-1-(Trifluoromethyl)phenethylamine HCl; (S)-(-)-α-(Trifluoromethyl)benzylamine HCl; (S)-1-Phenyl-2,2,2-trifluoroethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-Phenylethylamine HCl is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.