Description

(S)-2-((1R,3As,7Ar,E)-4-((E)-2-((3S,5R)-3,5-Bis(tert-Butyldimethylsilyloxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propan-1-Ol is a sophisticated, high-purity synthetic intermediate featuring a complex steroidal-like framework with strategically protected hydroxyl groups. This compound is of significant value in advanced organic synthesis, particularly for constructing chiral, polycyclic molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, especially those targeting hormonal pathways or requiring specific three-dimensional stereochemistry.
• Steroid Analog Synthesis: Used in research to create novel steroid derivatives or analogs for biological evaluation and structure-activity relationship (SAR) studies.
• Asymmetric Catalysis Ligand Precursor: The protected diol and defined stereocenters make it a potential precursor for developing novel chiral ligands or organocatalysts.
• Fine Chemical Production: Employed in the manufacture of high-value, low-volume specialty chemicals where precise stereochemical control is paramount.
• Academic & Industrial Research: Serves as a critical reagent in methodological development for complex molecule synthesis and total synthesis projects.

Basic Information

Item	Details
Product Name	(S)-2-((1R,3As,7Ar,E)-4-((E)-2-((3S,5R)-3,5-Bis(tert-Butyldimethylsilyloxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propan-1-Ol
CAS No.	128387-35-9
Molecular Formula	C37H68O3Si2
Molecular Weight	617.11 g/mol
Synonyms	(S)-2-((1R,3As,7Ar,E)-4-((E)-2-((3S,5R)-3,5-Bis(TBDMS-oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol; (S)-2-[(1R,3aS,7aR,E)-4-[(E)-2-[(3S,5R)-3,5-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-3a,4,5,6,7,7a-hexahydro-1H-inden-1-yl]propan-1-ol; Steroid TBS Diol Intermediate; 1-Propanol, 2-[(1R,3aS,7aR,E)-4-[(E)-2-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-1-cyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl]-, (2S)-
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, critical for sensitive downstream reactions. Our quality assurance includes comprehensive analytical characterization using techniques such as HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.