Description

(+/-)-2,3-Dihydro-6-Methoxy-3-(((Methylsulfonyl)Oxy)Methyl)-1H-Indole- 1-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its indole-based structure with a mesylate ester protecting group. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling precise chemical transformations. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for developing new therapeutic molecules.
• Process Chemistry Development: Serves as a standard or starting material for scaling up and optimizing synthetic routes in pilot plants and manufacturing.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Academic Research: Utilized in university and institutional labs for studying organic reaction mechanisms and developing new synthetic methodologies.

Basic Information

Product Name	(+/-)-2,3-Dihydro-6-Methoxy-3-(((Methylsulfonyl)Oxy)Methyl)-1H-Indole- 1-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	127943-74-2
Molecular Formula	C16H21NO6S
Molecular Weight	355.41 g/mol
Synonyms	tert-Butyl 6-methoxy-3-((methylsulfonyloxy)methyl)-2,3-dihydro-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 2,3-dihydro-6-methoxy-3-[[(methylsulfonyl)oxy]methyl]-, 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-6-methoxy-3-((methylsulfonyloxy)methyl)indoline; BOC-6-Methoxy-3-(mesyloxymethyl)indoline; 3-(Mesyloxymethyl)-6-methoxy-1-BOC-indoline; 1-BOC-6-Methoxy-3-(methylsulfonyloxymethyl)indoline; (±)-1-Boc-6-methoxy-3-(mesyloxymethyl)indoline
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP manufacturing needs with traceable documentation and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.