Description

6-Bromo-7-fluoroquinoline is a high-purity, multi-functional halogenated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in antimicrobial and anticancer research, leveraging the quinoline scaffold's bioactivity.
• Agrochemical Synthesis: Used to develop advanced pesticides and herbicides, where the halogen atoms can be further functionalized to modulate biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functional unit in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: The nitrogen atom in the quinoline ring makes it a suitable candidate for designing novel chelating ligands in transition metal catalysis.
• Fluorine Chemistry Building Block: The presence of fluorine allows for further selective chemical transformations, useful in medicinal chemistry for improving metabolic stability and membrane permeability.
• Cross-Coupling Reactions: The bromine substituent acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.

Basic Information

Product Name	6-Bromo-7-fluoroquinoline
CAS No.	127827-52-5
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	7-Fluoro-6-bromoquinoline; Quinoline, 6-bromo-7-fluoro-; 6-Bromo-7-fluoro-quinoline; 127827-52-5; 6-Br-7-F-quinoline
EINECS	Contact for details

Quality Control

Our 6-Bromo-7-fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.