Description

Ethyl 7-Chloro-1-Cyclopropyl-6-Nitro-4-Oxo-1,4-Dihydro-3-Quinolinecarboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel fluoroquinolone antibiotics, enabling the development of next-generation antimicrobial agents. It is primarily sought by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in active pharmaceutical ingredient (API) production.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: A vital precursor in the multi-step synthesis of potent antibacterial agents targeting DNA gyrase and topoisomerase IV.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, optimization, and scale-up of new antibacterial drug candidates.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in regulated GMP production processes for the commercial synthesis of antibiotic APIs.
• Chemical Synthesis Studies: Serves as a model compound for studying quinolone chemistry, nitration reactions, and ester transformations.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.

Basic Information

Product Name	Ethyl 7-Chloro-1-Cyclopropyl-6-Nitro-4-Oxo-1,4-Dihydro-3-Quinolinecarboxylate
CAS No.	127625-17-6
Molecular Formula	C₁₅H₁₃ClN₂O₅
Molecular Weight	336.73 g/mol
Synonyms	7-Chloro-1-cyclopropyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; Ethyl 7-chloro-1-cyclopropyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate; 1-Cyclopropyl-7-chloro-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid Ethyl Ester; Quinolone Intermediate 127625-17-6; Fluoroquinolone Intermediate; Antibiotic Intermediate; EC6N
EINECS	Contact for details

Quality Control

Our Ethyl 7-Chloro-1-Cyclopropyl-6-Nitro-4-Oxo-1,4-Dihydro-3-Quinolinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent specifications required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.