Description

Tetrofosmin is a radiopharmaceutical complexing agent, specifically a diphosphine ligand, used to form technetium-99m complexes for diagnostic imaging. Its primary value lies in its critical role in the preparation of Technetium Tc 99m Tetrofosmin, a vital myocardial perfusion imaging agent used in nuclear cardiology. This product is essential for pharmaceutical manufacturers, radiopharmacies, and research institutions developing or producing cardiac diagnostic kits.

Application

• Primary raw material for the synthesis of Technetium Tc 99m Tetrofosmin injection.
• Key component in the manufacturing of cold kits for myocardial perfusion imaging (MPI).
• Used in radiopharmaceutical research and development for cardiac diagnostics.
• Critical for studies investigating heart muscle viability and coronary artery disease.
• Application in the development of standardized pharmaceutical grade reagents for nuclear medicine.
• Used in quality control laboratories for reference standard preparation.

Basic Information

Product Name	Tetrofosmin
CAS No.	127502-06-1
Molecular Formula	C22H52O6P4
Molecular Weight	564.55 g/mol
Synonyms	1,2-Bis[bis(2-ethoxyethyl)phosphino]ethane; Tetrofosmin (ligand); P53; HM-PAO (related class); Cardiolite precursor ligand; Myoview kit component; Technetium Tc 99m Tetrofosmin precursor; Bis(2-ethoxyethyl)[2-[bis(2-ethoxyethyl)phosphino]ethyl]phosphine
EINECS	Contact for details

Quality Control

Our Tetrofosmin is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) that detail compliance with in-house specifications aligned with ICH guidelines. Documentation supports regulatory filings for drug master files (DMF) or investigational applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.