Description

3-tert-Butyldiphenylsiloxy-2,3,3A,7A-Tetrahydrobenzo(B)Thiophen-5(4H)-One 1,1-Dioxide is a high-value, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a sulfone and a silyl ether protecting group. This compound is critical for its role in the synthesis of complex organic molecules, particularly in medicinal chemistry where it serves as a key building block. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in multi-step synthetic routes for novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory research.
• Organic Synthesis Building Block: Utilized in constructing complex heterocyclic frameworks due to its reactive ketone and protected alcohol functionalities.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the synthesis of targeted molecular libraries for high-throughput screening.
• Process Chemistry Development: Used in scaling up synthetic pathways from laboratory to pilot plant scale for potential commercial API manufacturing.
• Academic Research: A valuable reagent for universities and institutes studying new synthetic methodologies and reaction mechanisms involving silyl ethers and sulfones.

Basic Information

Product Name	3-tert-Butyldiphenylsiloxy-2,3,3A,7A-Tetrahydrobenzo(B)Thiophen-5(4H)-One 1,1-Dioxide
CAS No.	127486-99-1
Molecular Formula	C26H30O4SSi
Molecular Weight	466.68 g/mol
Synonyms	3-[(tert-Butyldiphenylsilyl)oxy]-2,3,3a,7a-tetrahydrobenzo[b]thiophene-5(4H)-one 1,1-dioxide; 3-(tert-Butyldiphenylsiloxy)-2,3,3a,7a-tetrahydrobenzo[b]thiophene-5(4H)-one S,S-dioxide; TBDPS-protected tetrahydrobenzothiophene sulfone; CAS 127486-99-1; 3-TBDPSO-tetrahydrobenzo[b]thiophene-5-one dioxide; Benzo[b]thiophene sulfone TBDPS ether.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced under GMP-like conditions suitable for non-clinical research, specifications can be tailored to meet the rigorous demands of process development and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.