Description

Benzyl-Peg3-Acid CAS NO 127457-63-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a benzyl-protected carboxylic acid group. This compound is a critical intermediate for the synthesis of bioconjugates, enabling the precise attachment of therapeutic or diagnostic agents to biomolecules. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality linkers for developing advanced drug delivery systems, antibody-drug conjugates (ADCs), and diagnostic probes.

Application

• Bioconjugation Linker: A key building block for creating stable, cleavable, or non-cleavable linkages in antibody-drug conjugates (ADCs), peptide-drug conjugates, and protein-polymer conjugates.
• PEGylation Reagent: Used to introduce hydrophilic PEG spacers onto drugs, proteins, or nanoparticles to improve solubility, reduce immunogenicity, and enhance circulation half-life.
• Protease-Cleavable Substrate: The benzyl ester group can be designed as a substrate for specific enzymes (e.g., cathepsin B), enabling targeted drug release in tumor microenvironments.
• Polymer Chemistry Intermediate: Serves as a functional monomer or chain terminator in the synthesis of functionalized polymers and hydrogels for biomedical applications.
• Surface Functionalization: Used to modify the surface of materials, nanoparticles, or biosensors with carboxylic acid groups for further covalent coupling of ligands or biomolecules.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a side-chain protected or linker molecule for the synthesis of complex peptides and peptidomimetics.

Basic Information

Product Name	Benzyl-Peg3-Acid
CAS No.	127457-63-0
Molecular Formula	C17H26O6
Molecular Weight	326.39 g/mol
Synonyms	3-[2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy]-propionic acid; Benzyl-triethylene glycol acetic acid; Benzyl-PEG3-CH2COOH; 2-[2-(2-Benzyloxyethoxy)ethoxy]ethyl 3-carboxypropyl ether; Benzyl-O-(CH2CH2O)3-CH2CH2COOH; Bn-PEG3-COOH; Benzyl-PEG3-propionic acid
EINECS	Contact for details

Quality Control

Our Benzyl-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen) is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.