Description

9-Oxabicyclo[6.1.0]Non-3-Yne CAS NO 127302-48-1 is a strained bicyclic organic compound featuring both an oxirane (epoxide) ring and a cyclooctyne moiety, making it a valuable bifunctional building block in advanced organic synthesis. Its unique structure provides a versatile platform for click chemistry applications, particularly in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, which are critical for bioconjugation and materials science. This high-value intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and the creation of functional polymers and advanced materials.

Application

• Bioconjugation and Probe Development: Serves as a key reagent in strain-promoted azide-alkyne cycloaddition (SPAAC) for labeling biomolecules (proteins, antibodies, nucleic acids) without cytotoxic copper catalysts.
• Pharmaceutical Intermediate: Used in the synthesis of complex drug candidates, leveraging its strained alkyne for selective coupling reactions to build novel molecular architectures.
• Materials Science and Polymer Chemistry: Acts as a functional monomer or cross-linker for creating smart polymers, hydrogels, and surface-modified materials with tailored properties.
• Chemical Biology Tool: Enables the study of biological processes through bioorthogonal chemistry for live-cell imaging and activity-based protein profiling.
• Agrochemical Research: Employed in the synthesis of novel active ingredients and formulation additives.
• Academic and R&D Laboratories: A fundamental reagent for methodological development in synthetic organic chemistry and catalysis.

Basic Information

Product Name	9-Oxabicyclo[6.1.0]Non-3-Yne
CAS No.	127302-48-1
Molecular Formula	C8H10O
Molecular Weight	122.16 g/mol
Synonyms	9-Oxabicyclo[6.1.0]non-3-yne; Bicyclo[6.1.0]non-3-yne, 9-oxa-; 9-Oxa-bicyclo[6.1.0]non-3-yne; Oxirane-fused cyclooctyne; SPAAC reagent; Cyclooctyne epoxide; BCN-O (common abbreviation); Difunctional strained alkyne
EINECS	Contact for details

Quality Control

Our 9-Oxabicyclo[6.1.0]Non-3-Yne is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with relevant REACH regulations for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, we recommend storage at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent potential degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.