Description

(2S)-1-Amino-2-Pyrrolidinemethanol CAS NO 127221-89-0 is a chiral, non-natural amino alcohol derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its bifunctional structure, featuring both a primary amine and a secondary alcohol, which makes it a versatile precursor for constructing complex molecular architectures, particularly in the pharmaceutical sector. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), chiral ligands, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of various drug candidates, including protease inhibitors and other biologically active molecules.
• Chiral Ligand & Catalyst Preparation: Used to synthesize novel chiral auxiliaries and ligands for asymmetric catalysis, enhancing enantioselectivity in critical reactions.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and development of peptidomimetic compounds for medicinal chemistry applications.
• Fine Chemical Synthesis: A versatile building block for creating complex, high-value specialty chemicals used in agrochemicals and material science.
• Academic & R&D Laboratories: Employed in research settings for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	(2S)-1-Amino-2-Pyrrolidinemethanol
CAS No.	127221-89-0
Molecular Formula	C5H12N2O
Molecular Weight	116.16 g/mol
Synonyms	(2S)-2-Pyrrolidinemethanol, 1-Amino-; (S)-1-Amino-2-(hydroxymethyl)pyrrolidine; L-1-Amino-2-pyrrolidinemethanol; (S)-(-)-1-Amino-2-pyrrolidinemethanol; 1-Amino-(2S)-pyrrolidine-2-methanol; (2S)-1-Amino-2-(hydroxymethyl)pyrrolidine; Pyrrolidine, 1-amino-2-(hydroxymethyl)-, (2S)-
EINECS	Contact for details

Quality Control

Our (2S)-1-Amino-2-Pyrrolidinemethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.