Description

3-Quinolinecarboxylic Acid, 8-Chloro-6,7-Difluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-substituted quinoline core structure. This compound is of critical importance in the synthesis of novel fluoroquinolone antibiotics, where its specific stereochemistry and halogenation pattern are essential for imparting targeted biological activity and optimizing pharmacokinetic profiles. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial agents and other fine chemical applications.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a crucial building block in the synthesis of advanced, broad-spectrum antibacterial agents.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the discovery and optimization of new drug candidates targeting bacterial infections.
• Process Chemistry & Scale-Up: Employed in the development and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Chemical Biology Studies: Utilized as a probe or precursor in studying enzyme interactions and biological pathways.
• Fine Chemical Synthesis: Acts as a specialized synthon for constructing complex heterocyclic compounds in advanced organic synthesis.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 8-Chloro-6,7-Difluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-
CAS No.	127199-27-3
Molecular Formula	C13H7ClF3NO3
Molecular Weight	329.65 g/mol
Synonyms	8-Chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; (1R,2S)-1-(8-Chloro-6,7-difluoro-4-oxo-1,4-dihydroquinolin-3-yl)-2-fluorocyclopropanecarboxylic acid; 127199-27-3; Advanced Fluoroquinolone Intermediate; (1R,2S)-2-Fluorocyclopropyl Quinolone Carboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical R&D and scale-up. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.