Description

3-Quinolinecarboxylic Acid, 8-Chloro-6,7-Difluoro-1-(2-Fluorocyclopropyl)-1,4-Dihydro-4-Oxo-,Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-halogenated quinoline structure. This compound is of critical importance for its role as a key building block in the synthesis of novel fluoroquinolone antibiotics, offering a pathway to molecules with enhanced potency and spectrum of activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial agents and other fine chemical applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of advanced fluoroquinolone antibiotic candidates.
• Antibacterial Drug Research: Serves as a core scaffold for medicinal chemistry programs aimed at discovering new antibacterial agents with improved efficacy against resistant strains.
• Chemical Synthesis: Used in organic synthesis for constructing complex heterocyclic systems, leveraging its reactive ester and ketone functionalities.
• Process Development: Employed in scale-up and optimization studies for the commercial production of target active pharmaceutical ingredients (APIs).
• Biochemical Research: May be utilized as a tool compound in studies investigating bacterial enzyme inhibition (e.g., DNA gyrase, topoisomerase IV).

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 8-Chloro-6,7-Difluoro-1-(2-Fluorocyclopropyl)-1,4-Dihydro-4-Oxo-,Ethyl Ester
CAS No.	127199-25-1
Molecular Formula	C₁₅H₁₁ClF₃NO₃
Molecular Weight	345.70 g/mol
Synonyms	8-Chloro-6,7-difluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester; Ethyl 8-chloro-6,7-difluoro-1-(2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate; 1-Cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester derivative; ABT-719 intermediate; Fluoroquinolone intermediate; 127199-25-1; 8-Chloro-6,7-difluoro-1-(2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 8-Chloro-6,7-Difluoro-1-(2-Fluorocyclopropyl)-1,4-Dihydro-4-Oxo-,Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.