Description

α-D-Gal-[1->4]-β-D-Gal-[1->4]-β-D-Glc-1->o-Sphingosine CAS NO 126550-86-5 is a defined, high-purity glycosphingolipid, specifically a globotriaosylceramide (Gb3) derivative. This compound is a critical biochemical tool and reference standard for research into cellular recognition, signal transduction, and the pathogenesis of diseases like Fabry disease and certain bacterial infections. It is essential for scientists and manufacturers in the life sciences sector who require precise, well-characterized molecules for advanced research, diagnostic development, and therapeutic discovery.

Application

• Biochemical Research: Used as a high-purity reference standard and substrate in studies of glycosphingolipid metabolism, cell membrane structure, and lipid raft dynamics.
• Diagnostic Development: Serves as a critical antigen in the development of diagnostic assays and kits for Fabry disease and related lysosomal storage disorders.
• Toxicology & Pathogenesis Studies: Employed to investigate the binding mechanism of Shiga toxin and verotoxin to host cell receptors, aiding in the study of bacterial infections.
• Pharmaceutical R&D: Acts as a key intermediate or target molecule in drug discovery programs focused on enzyme replacement therapies and metabolic disease treatments.
• Cell Biology & Immunology: Utilized to study cell-cell interactions, immune response modulation, and the role of specific glycolipids in cellular signaling pathways.
• Quality Control & Standardization: Provides a certified reference material for the calibration and validation of analytical methods in pharmaceutical and diagnostic manufacturing.

Basic Information

Product Name	α-D-Gal-[1->4]-β-D-Gal-[1->4]-β-D-Glc-1->o-Sphingosine
CAS No.	126550-86-5
Molecular Formula	C46H85NO18
Molecular Weight	940.16 g/mol
Synonyms	Globotriaosylceramide (Gb3); CD77 Antigen; Ceramide Trihexoside (CTH); Gal(alpha1-4)Gal(beta1-4)Glc(beta1-1')Cer; Gb3Cer; Pk Antigen; Shiga Toxin Receptor; Globotriaose Ceramide; Fabry Disease Lipid; α-D-Galactosyl-(1->4)-β-D-galactosyl-(1->4)-β-D-glucosyl-(1<->1)-N-acylsphingosine
EINECS	Contact for details

Quality Control

Our α-D-Gal-[1->4]-β-D-Gal-[1->4]-β-D-Glc-1->o-Sphingosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity, and impurity profile. We adhere to relevant industry guidelines to support our clients' compliance needs in pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.