Description

(R)-(+)-2-Piperazinecarboxylic Acid Dihydrochloride is a high-purity chiral building block and intermediate of significant importance in pharmaceutical research and development. Its value lies in its role as a key precursor for synthesizing complex molecules, particularly those with specific stereochemical requirements. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Peptidomimetic Research: Serves as a constrained amino acid analogue in the design and development of peptide-based drugs and enzyme inhibitors.
• Asymmetric Synthesis: Used as a starting material or catalyst ligand in stereoselective chemical reactions to produce enantiomerically pure compounds.
• Agrochemical Development: Employed in the research of new pesticides and herbicides where specific chirality impacts biological activity.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A key raw material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	(R)-(+)-2-Piperazinecarboxylic Acid Dihydrochloride
CAS No.	126330-90-3
Molecular Formula	C5H12N2O2 • 2HCl
Molecular Weight	225.09 g/mol
Synonyms	(R)-(+)-Piperazine-2-carboxylic Acid Dihydrochloride; D-Piperazine-2-carboxylic Acid Dihydrochloride; (R)-2-Piperazinecarboxylic Acid Dihydrochloride; (2R)-Piperazine-2-carboxylic Acid Dihydrochloride; (R)-Pipecolic Acid Dihydrochloride (related); D-Pipecolic Acid Dihydrochloride (related); (R)-PCA Dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-(+)-2-Piperazinecarboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.