Description

4-(((tert-Butyldimethylsilyl)Oxy)Methyl)Phenol is a versatile organosilicon-protected phenolic intermediate of significant importance in synthetic organic chemistry. Its core value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which provides exceptional stability for the phenolic hydroxyl during multi-step synthesis. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where selective protection of phenol groups is required.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators that contain phenolic moieties.
• Liquid Crystal & OLED Material Precursor: Serves as a protected intermediate in the production of organic electronic materials and display components.
• Polymer & Resin Modification: Employed to introduce stable, protected phenolic functionalities into polymer backbones for specialty coatings and adhesives.
• Complex Natural Product Synthesis: Facilitates the multi-step total synthesis of complex natural products in academic and industrial research settings.
• Peptide & Carbohydrate Chemistry: Used as a protecting group strategy in the synthesis of modified peptides and complex sugars.

Basic Information

Product Name	4-(((tert-Butyldimethylsilyl)Oxy)Methyl)Phenol
CAS No.	126070-20-0
Molecular Formula	C13H22O2Si
Molecular Weight	238.40 g/mol
Synonyms	4-((tert-Butyldimethylsilyloxy)methyl)phenol; p-((tert-Butyldimethylsilyloxy)methyl)phenol; 4-(Hydroxymethyl)phenol TBDMS ether; Phenol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-; TBDMS ether of 4-Hydroxybenzyl alcohol; 4-(TBDMS-oxymethyl)phenol; 4-Hydroxybenzyl alcohol tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our production of 4-(((tert-Butyldimethylsilyl)Oxy)Methyl)Phenol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by modern analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can compromise product integrity. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.