Description

2-Iodo-4-Azidophenol is a versatile bifunctional aromatic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an iodine and an azide functional group, makes it an invaluable reagent for click chemistry, bioconjugation, and the development of photoaffinity labels. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require reliable, high-quality building blocks for complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for targeted therapies and diagnostic agents.
• Click Chemistry Reagent: Used in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for bioconjugation and polymer synthesis.
• Photoaffinity Labeling (PAL): The azide group acts as a photoactivatable crosslinker for studying protein-ligand interactions and mapping biological binding sites.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and plant growth regulators with specific modes of action.
• Materials Science: Building block for functional polymers, dendrimers, and smart materials requiring specific photo-responsive or cross-linking properties.
• Chemical Biology Probes: Synthesis of activity-based probes (ABPs) and imaging agents for cellular and biochemical studies.

Basic Information

Product Name	2-Iodo-4-Azidophenol
CAS No.	125728-62-3
Molecular Formula	C6H4IN3O
Molecular Weight	261.02 g/mol
Synonyms	4-Azido-2-iodophenol; 2-Iodo-4-azidophenol; Phenol, 2-iodo-4-azido-; 4-Hydroxy-3-iodophenyl azide; 3-Iodo-4-hydroxyphenyl azide; Azidophenol, iodo-; Iodoazidophenol
EINECS	Contact for details

Quality Control

Our 2-Iodo-4-Azidophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our commitment to quality ensures the material meets the stringent requirements for research and cGMP-grade manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, well-ventilated area, away from heat sources and incompatible materials. Due to its light-sensitive and easily oxidized nature, handling should be performed under controlled conditions.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.