Description

2-Chloro-1,3-Dimethylimidazolinium is a highly reactive chlorinating and dehydrating agent widely used in organic synthesis. This compound matters for its exceptional efficiency in activating carboxylic acids to form amides, esters, and peptides under mild conditions, offering a superior alternative to traditional, harsher reagents. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules and developing scalable synthetic routes.

Application

• Peptide Coupling Reagent: A key reagent for the formation of peptide bonds in solid-phase and solution-phase peptide synthesis, minimizing racemization.
• Esterification and Amidation: Efficiently activates carboxylic acids for condensation with alcohols or amines to produce esters and amides, crucial in medicinal chemistry.
• Nucleic Acid Chemistry: Used in the synthesis of oligonucleotides and nucleotide analogs as a phosphorylating or condensing agent.
• Polymer Chemistry: Serves as a catalyst or activating agent in the polymerization of specific monomers and the modification of polymer backbones.
• Intermediate for Heterocyclic Synthesis: Acts as a building block or activating agent in the construction of complex heterocyclic scaffolds important for drug discovery.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and other tools for studying enzyme function and protein interactions.

Basic Information

Product Name	2-Chloro-1,3-Dimethylimidazolinium
CAS No.	125376-11-6
Molecular Formula	C5H9ClN2
Molecular Weight	132.59 g/mol
Synonyms	1,3-Dimethyl-2-chloroimidazolinium; DMC; 2-Chloro-1,3-dimethyl-2-imidazolinium; 2-Chloro-1,3-dimethylimidazolinium chloride; 1,3-Dimethyl-2-chloro-4,5-dihydroimidazolium; 2-Chloro-4,5-dihydro-1,3-dimethyl-1H-imidazolium; Chloro-dimethylimidazolinium; CDI (Note: not to be confused with Carbonyldiimidazole)
EINECS	Contact for details

Quality Control

Our 2-Chloro-1,3-Dimethylimidazolinium is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.