Description

(S)-1,1,1-Trifluoroisopropylamine Hydrochloride is a high-purity chiral building block essential for introducing the trifluoromethyl group and a specific stereocenter into complex molecules. This compound matters because it enables the synthesis of advanced pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptide Modification: Incorporates fluorinated amino acid analogs into peptides to study structure-activity relationships and enhance peptide stability.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with unique surface properties.
• Diagnostic Reagent Precursor: Used in the manufacture of reagents and probes for imaging and biochemical assays.

Basic Information

Product Name	(S)-1,1,1-Trifluoroisopropylamine Hydrochloride
CAS No.	125353-44-8
Molecular Formula	C3H7ClF3N
Molecular Weight	149.54 g/mol
Synonyms	(S)-1-Amino-2,2,2-trifluoropropane hydrochloride; (S)-2,2,2-Trifluoroisopropylamine hydrochloride; (S)-1,1,1-Trifluoropropan-2-amine hydrochloride; (S)-α-Trifluoromethyl ethylamine hydrochloride; (S)-TFIPA HCl; (S)-Trifluoroisopropylamine HCl; (S)-1,1,1-Trifluoro-2-propylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1,1,1-Trifluoroisopropylamine Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.