Description

4,5,6,7-Tetrafluoro-1H-Indole-3-Carboxylic Acid is a high-value, multi-fluorinated indole derivative that serves as a critical building block in advanced organic synthesis. Its unique tetrafluoro-substituted indole scaffold is prized for introducing significant electronic and steric effects into target molecules, enhancing their metabolic stability and binding affinity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to develop novel fluorinated pesticides and herbicides, where the fluorine atoms improve lipophilicity and environmental stability.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a probe or labeling reagent due to the distinct properties imparted by the fluorine atoms.
• Academic & R&D: A valuable reagent for methodological studies in fluorination chemistry and heterocyclic compound synthesis.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for bespoke client projects requiring complex fluorinated heterocycles.

Basic Information

Product Name	4,5,6,7-Tetrafluoro-1H-Indole-3-Carboxylic Acid
CAS No.	124614-50-2
Molecular Formula	C9H3F4NO2
Molecular Weight	233.12 g/mol
Synonyms	4,5,6,7-Tetrafluoroindole-3-carboxylic acid; 1H-Indole-3-carboxylic acid, 4,5,6,7-tetrafluoro-; 4,5,6,7-Tetrafluoro-1H-indole-3-carboxylic acid; 3-Carboxy-4,5,6,7-tetrafluoroindole; Tetrafluoroindole-3-carboxylic acid; TFICA; 124614-50-2 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 4,5,6,7-Tetrafluoro-1H-Indole-3-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) including HPLC purity, identity confirmation (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.