Description

(S)-1,4-Dithia-7-Azaspiro[4.4]Nonane-8-Carboxylic Acid is a high-purity chiral building block featuring a unique spirocyclic structure containing sulfur and nitrogen heteroatoms. This compound is valued for its role as a key intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and metabolic disorders. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Serves as a precursor for constructing complex, stereochemically defined molecular architectures in organic synthesis.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of advanced therapeutics.
• Ligand and Catalyst Development: Potential use in the design of novel chiral ligands or organocatalysts due to its rigid, heteroatom-rich framework.

Basic Information

Product Name	(S)-1,4-Dithia-7-Azaspiro[4.4]Nonane-8-Carboxylic Acid
CAS No.	124492-04-2
Molecular Formula	C7H9NO2S2
Molecular Weight	203.28 g/mol
Synonyms	(S)-8-Carboxy-1,4-dithia-7-azaspiro[4.4]nonane; (7S)-1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid; L-1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid; Spirocyclic cysteine derivative; (S)-Spiro[1,4-dithia-7-azacyclopentane-8,1'-cyclopropane]-8'-carboxylic acid; Dithiaazaspiro nonane carboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-1,4-Dithia-7-Azaspiro[4.4]Nonane-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.