Description

1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-7-(2,6-Dimethyl-4-Pyridinyl)-4-Oxo-3-Quinolinecarboxyic Acid is a high-purity advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of modern fluoroquinolone antibiotics, valued for its precise molecular architecture. It is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Key Intermediate for Antibiotic Synthesis: Primary building block for the production of novel fluoroquinolone-class antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of new drug candidates.
• Active Pharmaceutical Ingredient (API) Manufacturing: Integral component in the multi-step synthesis of final bulk drug substances.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for optimizing synthetic routes and scaling production.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs producing specialized APIs for global pharmaceutical clients.
• Analytical Standard: Used as a high-purity reference standard for quality control and regulatory testing in API production.

Basic Information

Product Name	1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-7-(2,6-Dimethyl-4-Pyridinyl)-4-Oxo-3-Quinolinecarboxyic Acid
CAS No.	123942-05-2
Molecular Formula	C20H18F2N2O3
Molecular Weight	372.37 g/mol
Synonyms	1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid; 7-(2,6-Dimethyl-4-pyridinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432 Intermediate; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-; Difloxacin pyridine intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and MS to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting regulatory compliance for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.